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The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be fatalsee section 4.2)
Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleedingsuch as oral corticosteroidsanticoagulants such as warfarinselective serotonin-reuptake inhibitors or anti-platelet agents such as aspirinsee section 4.5
Taking etodolac and digoxin together may increase your risk of kidney damage.
Taking etodolac and cyclosporine together may increase your risk of kidney damage.
Oedemahypertension and cardiac failure have been reported in association with NSAID treatment.
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the discontinuation rate in controlled clinical trials, because of adverse events, was up to 10 for patients treated with etodolac.